Merck stops testing combo drug for lung cancer, ET HealthWorld

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Merck stops testing combo ***** for lung *******, ET HealthWorld

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London: Merck said on Thursday it had discontinued a trial testing a combination immunotherapy treatment in patients with a type of lung ******* after an interim analysis showed the ***** was unlikely to succeed.

The patients tested with a combination of its experimental *****, vibostolimab, with Keytruda experienced a higher rate of immune-related side effects, Merck said, adding that patients should stop ongoing treatment with the therapy.

The discontinuation marked yet another setback for vibostolimab and the promising new class of immunotherapies called anti-TIGIT to which it belongs.

Gilead Sciences, Roche and GSK are among half a dozen drugmakers looking to grab a share of the lucrative anti-TIGIT ******* ***** market, but the field has experienced multiple setbacks.

Vibostolimab works by selectively binding itself to TIGIT, a receptor on immune cells, to activate the immune system against ******* cells and prevent a misguided immune ******* against healthy cells.

Merck was testing vibostolimab along with Keytruda as a first-line treatment for patients with extensive-stage small cell lung ******* in the late-stage study.

Last year, the combination therapy had ******* to significantly slow ******** progression in lung ******* patients who did not respond to previous treatments.

The drugmaker discontinued another late-stage study in May testing the combination therapy in patients with a severe form of skin ******* after side effects led to high discontinuation.

(Reporting by Leroy Leo in Bengaluru; Editing by Devika Syamnath)

• Published On Aug 8, 2024 at 05:36 PM IST

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