Scientists Develop New Compound That May Help Fight Elusive Cancer Types

[Pelican Press 0]

Scientists Develop New Compound That May Help ****** Elusive ******* Types

Marking a significant breakthrough in the research for ******* treatments, scientists have developed a compound that can ***** some hard-to-treat ******* types. The findings are part of a new study published recently in the Nature Science. The new compound targets the vulnerability that wasn’t explored by researchers before. According to study leader and professor of obstetrics and gynecology at UT Health Centre at San Antonio, Ratna Vadlamudi, PhD, the scientists identified a critical vulnerability in multiple cancers and validated the findings in multiple ******* cell types and animal models.

The professor

This is the hidden content, please

• Sign In
• or
• Sign Up

that the compound was found to have worked on a range of cell lines and xenografts, which shows it is “targeting a fundamental vulnerability in ******* cells.” Vadlamudi and his colleagues had

This is the hidden content, please

• Sign In
• or
• Sign Up

a compound called ERX-11 while working at the Ratna Vadlamudi Lab, University of Texas Health Centre at San Antonio in 2017. The lab is geared up towards developing small-molecule inhibitors for therapy-resistant cancers by studying ovarian and ******* cancers.

The ERX-11 compound targets the estrogen receptor (ER), which is the leading cause behind most of the ******* cancers. After the compound was identified, scientists scanned through a screen of chemical analogs of ERX-11 and observed that another compound named ERX-41 was effective in ******** ER-positive cancers in petri dishes. It was also found that the compound managed to eliminate triple-negative ******* cancers (TNBCs). The finding was significant as there is a lack of targeted treatments for TNBC due to the absence of progesterone, estrogen, and human epidermal growth factor 2 in it.

Casting the net wider, scientists, using mouse models, highlighted that ERX-41 also showed activity against a large number of human tumours. It was learned that the compound effectively shrunk the tumours in mouse models without resulting in toxicity in the animals or affecting normal ******* cells.

In addition, ERX-41 proved to be working against other ******* types with elevated endoplasmic reticulum stress. These include cancers that don’t have many effective treatments for them like ovarian cancers, glioblastoma, and pancreatic cancers.

Scientists hope that the findings would help in development of new drugs bolstering the ****** against some cancers.

---

Affiliate links may be automatically generated – see our ethics statement for details.

This is the hidden content, please

• Sign In
• or
• Sign Up

scientists develop compound help ****** elusive ******* types *******,******* cells,compound
#Scientists #Develop #Compound #****** #Elusive #******* #Types

This is the hidden content, please

• Sign In
• or
• Sign Up