Ancient viruses in the human genome linked to mental health conditions

[Pelican Press 0]

Ancient viruses in the human genome linked to mental health conditions

Human endogenous retroviruses are remnants of viral genes in the human genome

NICOLLE R. FULLER/SCIENCE PHOTO LIBRARY

Ancient viruses embedded in human DNA millions of years ago may play a role in raising people’s risks of depression, schizophrenia and bipolar disorder. The viral genes have unusual activity levels in people who have a higher genetic risk of experiencing these mental health conditions, a study has found.

Retroviruses are a large group of viruses whose life cycle involves inserting their genetic information into the DNA of their host. Remnants of such viral genes can be seen in the DNA of many animal species, and these sequences are called human endogenous retroviruses (HERVs) when found in the human genome.

Until recently, most HERVs were thought to remain dormant and were called “fossil viruses”. But previous studies have suggested that some of the viral genes may in fact be active – although not producing infectious viruses – and may even play a role in neurological conditions,

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In a new study,

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at King’s College London and his colleagues investigated the possible role of these viral remnants in mental health conditions by looking at viral proteins in nearly 800 brains that had been donated for medical research.

While the team didn’t record if any of the donors had been diagnosed with mental health conditions while alive, they found that some genetic variants that are known to raise the risks of depression, schizophrenia and bipolar disorder were associated with altered activity of genes from five different HERVs.

It wasn’t possible to estimate how much of a raised risk was linked with the unusual viral gene activity, but it is probably in the range of a few per cent, as most human gene variants affect psychiatric risk by such small amounts, says Powell.

The findings also don’t necessarily mean that the altered HERV activity is causing the conditions – it could be a consequence, he says.

“The methods used look pretty robust,” says

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at the University of Nottingham in the ***. “The results are likely real that these things are markers of these *********, but [the researchers] are rightly cautious in saying they don’t know what that means.”

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mental health
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