Immunotherapy drug doubles cancer survival in breakthrough trial

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Immunotherapy drug doubles ******* survival in breakthrough trial

Philippa Roxby

Heath Reporter

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Laura now feels good six years after her diagnosis of advanced tongue *******

Hundreds of thousands of people with advanced head and neck ******* could live longer without their ******* returning thanks to an immunotherapy drug, a clinical trial suggests.

This is the first sign of a breakthrough for patients with this difficult-to-treat ******* for 20 years, say scientists behind the research.

Laura Marston, 45, from Derbyshire, says she is “amazed she’s still here” after being given “dire” chances of survival following a diagnosis of advanced tongue ******* six years ago.

She received the immunotherapy before and after surgery, which researchers say helps the body learn to attack the ******* if it returns.

Cancers in the head and neck are notoriously difficult to treat and there’s been little change in the way patients are treated in two decades.

More than half those diagnosed with advanced head and neck cancers die within five years.

Laura was given only a 30% chance of surviving that long after her diagnosis in 2019, after having an ulcer on her tongue which wouldn’t go away.

The next step was major surgery to remove her tongue, as well as lymph nodes in her neck, and then she had to learn to talk and eat again.

“I was 39 and I was devastated,” she told BBC News.

As part of an international study into new ways to treat the *******, involving experts from the Institute of ******* Research in London, Laura was one of more than 350 patients given the immunotherapy drug pembrolizumab before and after surgery to prime the body’s defences.

Prof Kevin Harrington, who led the trial in the ***, explains: “We give the immune system the chance to have a good look at the tumour to generate anti-tumour immunity and then, after removal of the tumour, we continue to amplify that immune response by giving the drug continually for up to a year.”

A similar number of patients diagnosed with similar cancers received the usual care offered. They all had advanced head and neck cancers in one area, that had not spread to the rest of the body.

The new approach showed positive results. It doubled the length of time patients were ******* free, on average, from around 2.5 years to five years.

After three years, patients given pembrolizumab had a 10% lower risk of their ******* returning elsewhere in the body.

‘Given me my life back’

Six years on, Laura is working full-time and says she’s “in a good place and doing really well”.

“It’s been phenomenal for me, because I’m here, able to talk to you.

“I wasn’t expected to come this far,” Laura says.

“My prognosis was quite dire.”

She had muscle taken from her left arm and placed into her mouth to fill the void left by her tongue. It has been a tough journey.

“Just having this amazing immunotherapy has given me my life back again.”

The researchers say the key to their results was giving patients the drug before surgery, which trains the body to hunt down and kill the ******* if it ever comes back.

Prof Harrington says immunotherapy “could change the world” for these patients.

“It significantly decreases the chance of ******* spreading around the body, at which point it’s incredibly difficult to treat,” he said.

About 12,800 new head and neck ******* cases are diagnosed in the *** every year.

The approach worked “particularly well” for some patients, but it was “really exciting” to see the treatment benefitting all the patients in the trial, Prof Harrington said. He added that it should now be made available on the NHS, .

The study findings are being presented at the American Society of Clinical Oncology (ASCO) annual meeting.

The trial, called Keynote, involved 192 hospitals in 24 countries, was led by Washington University Medical School in St Louis and funded by drug company MSD.

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