Chinese pharma companies eyeing strong foothold in therapeutic cancer vaccines market, ET HealthWorld

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******** pharma companies eyeing strong foothold in therapeutic ******* vaccines market, ET HealthWorld

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London: ******* vaccines represent a burgeoning field in oncology, potentially revolutionising ******* treatment. Earlier, approved ******* vaccines were prophylactic against *******-causing viruses. However, recent advancements have shifted towards developing therapeutic ******* vaccines, which focus on identifying tumour-specific antigens to create innovative ******* immunotherapies. In this context, ******** companies are actively positioning themselves to secure a strong foothold in the therapeutic vaccine market, says GlobalData:

According to GlobalData’s Pharmaceutical Intelligence Centre, seven ******* vaccines are approved in China, of these four were developed by multinational pharma companies. The homegrown vaccines include Wozehui, developed by Shanghai Zerun Biotechnology, and Cecolin, by Xiamen Innovax Biotechnology, both targeting different serotypes of HPV. Additionally, Rebys, produced by Cure & Sure Biotech, is an autologous heat shock protein-gp6 peptide complex, marking it as the first therapeutic ******* vaccine approved in China for multiple oncology indications, including oesophagal, gastric, pancreatic, and liver cancers.

Jithendra Kancharla, Pharma Analyst, GlobalData, commented, “Therapeutic ******* vaccines harness the body’s immune system to recognise and combat tumour cells within the body. They harbour an antigen specific to the tumour cells and present them to immune cells, eliciting them to ******* the antigen-containing tumour cells. The field of therapeutic ******* vaccines is advancing rapidly with technological innovations, driving promising research in areas such as personalised neoantigen vaccines, oncolytic virus-based vaccines, and mRNA ******* vaccines.”

A significant breakthrough was achieved in 2010 with the approval of sipuleucel-T (Provenge), developed by Dendreon Pharmaceuticals, for the treatment of advanced prostate *******. Provenge is an autologous cellular immunotherapy that marks a significant milestone as the first FDA-approved therapeutic ******* vaccine.

According to GlobalData’s Pharmaceutical Intelligence Centre, as of August 20, 2024, 23 different ******* vaccines are in Phase I to Phase III clinical development in China. Most of these vaccines (60 per cent) are therapeutic ******* vaccines and homegrown companies are developing the majority of them.

Notably, the US (Vaccine candidates duplicated across the focus geographies are segregated based on their developer’s (company) headquarters and categorised under the respective geography.) is leading the innovation of therapeutic ******* vaccines with 46 potential vaccine candidates in the pipeline, followed by Europe with 22 vaccine candidates, China with 14 and Japan with 11 therapeutic ******* vaccines in Phase I to Phase III clinical development.

Kancharla concluded, “Despite China forging ways to compete on a global level in the field of therapeutic ******* vaccines, the Western companies currently have a more advanced position, with several vaccine candidates showing potential for treating different areas of oncology. As these vaccines progress through clinical trials and reach commercialisation, China’s influence in oncology is likely to expand. The next decade could see China not only as a major market but also as a leading innovator in the global ****** against *******.”

• Published On Aug 26, 2024 at 12:03 PM IST

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